A new discovery paradigm to unlock intractable drug targets with exosites

Our Approach

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Exo Therapeutics is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.
diagram-exosight-platform

Team

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MichaelBruce-GRAY
ChristopherLiu-GRAY
PaulSchneider-GRAY
GhotasEvindar-GRAY
ShilpiArora-GRAY
DavidLiu-GRAY
AlanSaghatelian-GRAY
JPMaianti-GRAY
StuartSchreiber-GRAY
BenjaminEbert-GRAY
BenjaminCravatt-GRAY
CharlesRobert-GRAY
MichaelBruce-GRAY
AaronNelson-GRAY
TomCahill-GRAY
NageshMahanthappa-GRAY

Careers

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Current Opportunities

Senior/Principal Research Associate, Biochemistry

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Overview

Exo Therapeutics seeks a highly motivated Senior/Principal Research Associate with a strong background in biochemistry assay implementation and contributing to a multidisciplinary team in external and internal drug discovery activities. This position will be an integral part of the biochemistry team and will help drive the drug discovery programs forward. You will work across therapeutic functions with a primary focus in discovery and development of therapeutics in oncology, autoimmune and immuno-inflammation.

The senior/principal research associate will be expected to contribute to and complement our existing technical expertise to enhance and accelerate research. We are keen to identify someone who is a self-starter and proactive and who can work independently and effectively, both with the Exo team and external collaborators. The candidate will also participate in the build-out and maintenance of our growing laboratory environment.

Responsibilities

  • Perform routine biochemical screening of compounds, eg IC50, in house or in collaboration with external partners.
  • Communication and discussion of results with internal project teams, especially chemistry and biology.
  • Development of novel screening assays for use either in-house or for transfer to CRO’s.
  • Coordination of assay workflow locally and/or with the CRO partners, data analysis and presentation of results to the internal and external teams.
  • Employ biochemical and biophysical methods enabling mechanistic studies to determine the mode-of-inhibition for promising hits.
  • Propose and implement new experimental techniques and troubleshoot roadblocks in collaboration with the team.
  • Independently manage and order supplies/reagents in a timely manner to ensure continuous progress of parallel experimental workflows under your responsibility.
  • Management of laboratory equipment, including maintenance, vendor relations and service contracts.
  • Maintain good data records, protocols, and summaries. Analyze raw data and interpret integrated datasets using Prism, Vortex, or similar software packages.
  • Use of electronic lab notebook and data registration to corporate database. 
  • Take all opportunities to make intellectual contributions and discoveries.

Required Qualifications

  • Bachelor’s degree in a life sciences-related field with by a proven track-record of hands-on laboratory experience for 4-6 years, or a Master’s degree with 4+ years of research experience, respectively.
  • Strong foundation with a background in small molecule discovery/validation, biochemistry and biophysical methods.
  • Proficiency in experimental design and data analysis using Graphpad Prism, Excel or equivalent software.
  • Troubleshooting skills, analytical perseverance, with a strong ability to integrate advice.
  • Proficiency in results presentation, data documentation, and scientific communication.
  • Analyze, interpret, and effectively present scientific data at team meetings
  • Ability to work effectively with flexible supervision as a member of multiple project teams
  • Prior experience working with CRO partners highly preferred
  • Good problem-solving skills with excellent interpersonal skills and a collaborative work style

Desired technical competencies:

  • Assay development experience and capabilities such as FP, TR-FRET, AlphaScreen, etc.
  • Experience in mechanistic enzymology such as Ki, mode-of-inhibition, kinetics, etc.

Other complementary and transferable skills:

  • Molecular biology, protein expression, purification and characterization (for example: M/S, SEC, DLS, CD, SDS-PAGE, etc.
  • Working knowledge of biophysical methods such as SPR, MST, ITC, DSF, etc.
  • Familiarity with Cell-based assays (for example: BRET, iLite, DualGlo, CTGlo, HiBiT, CaspaseGlo, etc.)

All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to careers@exo-therapeutics.com

Sr. Scientist, Biochemistry

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Exo Therapeutics seeks a highly motivated senior scientist with a strong background in biochemistry assay implementation and contributing to a multidisciplinary team in external and internal drug discovery activities. This position will be an integral part of the biochemistry team and will help drive the drug discovery programs forward. You will work across therapeutic functions with a primary focus in discovery and development of therapeutics in oncology, autoimmune and immuno-inflammation.

The senior scientist will be expected to develop new biochemical assays and contribute to and complement our existing technical expertise to enhance and accelerate research. We are keen to identify someone who is a self-starter and proactive and who can work independently and effectively, both with the Exo team and external collaborators. The candidate will also participate in the build-out and maintenance of our growing laboratory environment.

Responsibilities

  • Proposal and develop new biochemical assays for compounds testing and mechanistic studies.
  • Propose and implement new experimental techniques and troubleshoot roadblocks in collaboration with the team.
  • Employ biochemical and biophysical methods enabling mechanistic studies to determine the mode-of-inhibition for promising hits.
  • Coordination of assay workflow locally and/or with the CRO partners, data analysis and presentation of results to the internal and external teams.
  • Perform routine biochemical screening of compounds, eg IC50, in house or in collaboration with external partners.
  • Communication and discussion of results with internal project teams, especially chemistry and biology.
  • Independently manage and order supplies/reagents in a timely manner to ensure continuous progress of parallel experimental workflows under your responsibility.
  • Management of laboratory equipment, including maintenance, vendor relations and service contracts.
  • Maintain good data records, protocols, and summaries. Analyze raw data and interpret integrated datasets using Prism, Vortex, or similar software packages.
  • Use of electronic lab notebook and data registration to corporate database.
  • Take all opportunities to make intellectual contributions and discoveries.


Required Qualifications

• Ph.D. in biochemistry or related discipline with postdoctoral training with a proven track-record with 3+ years of industrial experience
• Strong foundation with a background in small molecule discovery/validation, biochemistry and biophysical methods.
• Proficiency in experimental design and data analysis using Graphpad Prism, Excel or equivalent software.
• Troubleshooting skills, analytical perseverance, with a strong ability to integrate advice.
• Proficiency in results presentation, data documentation, and scientific communication.
• Analyze, interpret, and effectively present scientific data at team meetings
• Ability to work effectively and independently as a member of multiple project teams
• Prior experience working with CRO partners highly preferred
• Good problem-solving skills with excellent interpersonal skills and a collaborative work style

Desired technical competencies:

  • Assay development experience and capabilities such as FP, TR-FRET, AlphaScreen, etc.
  • Experience in mechanistic enzymology such as Ki, mode-of-inhibition, kinetics, etc.

 Other complementary and transferable skills:

  • Molecular biology, protein expression, purification and characterization (for example: M/S, SEC, DLS, CD, SDS-PAGE,
  • Working knowledge of biophysical methods such as SPR, MST, ITC, DSF, etc.
  • Familiarity with Cell-based assays (for example: BRET, iLite, DualGlo, CTGlo, HiBiT, CaspaseGlo, et

All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to careers@exo-therapeutics.com

Interested in joining our team? Explore careers

Senior Scientist, Medicinal Chemist, Chemical Biology, Biochemistry

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Exo Therapeutics seeks a highly motivated senior scientist with a strong background in synthetic medicinal chemistry, or chemical biology. You will be responsible for structural evaluation of protein constructs, tool and probe design, establishing new biochemical assay for validating exosite across therapeutic targets. You will work across a multidisciplinary team contributing to early target identification and progression of established programs across Exo portfolio.

As a senior scientist, you will be expected to contribute and complement our existing technical expertise at a critical stage of the company’s platform: identifying and validating novel exosites that will deliver extraordinary therapeutic opportunities. We are keen to identify a proactive self-starter and who is comfortable with independent research as well as effective teamwork, both with the Exo team and external collaborators. The candidate will also participate in the build-out and maintenance of our growing laboratory space.

Responsibilities

• Evaluate target proteins across the human proteome, propose new biochemical/biophysical assays, and deliver tools and probes to enable those assays.
• Enable new screening methods across the Exo portfolio.
• Support biochemical/biophysical assay and screening of compounds, eg IC50, in house or in collaboration with external partners.
• Work collaboratively with medicinal chemistry, computational chemistry, biochemistry and cell biology groups to deliver compelling drug discovery programs.
• Communicate and discuss results with internal project team members across multiple disciplines.
• Maintain good data records, protocols, and summaries. Analyze raw data and interpret integrated datasets using Prism, Vortex, or similar software packages

Required Qualifications

• Ph.D. in medicinal chemistry, chemical biology or related discipline with postdoctoral training and a proven track-record with 3+ years of industrial experience.
• Strong track record in novel biochemical assay development, use of small molecule probes in target discovery/validation, and biochemistry and biophysical method development.
• Experience with structural biology, computational chemistry, protein homology modeling.
• Proficiency in results presentation, data documentation, and written and oral communication.
• Foster teamwork in a collaborative environment.

All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to careers@exo-therapeutics.com

Interested in joining our team? Explore careers

Senior/Principal Scientist, Early Target Biology

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Exo Therapeutics seeks a highly motivated biologist with a strong background in signaling pathways and their perturbations in disease. This position will be an integral part of the biology group and will help drive the identification and validation of new targets for entry into the drug discovery portfolio. You will work across therapeutic functions with a primary focus in oncology and/or immunology. The scientist will extend our existing technical expertise to enhance and accelerate our platform development. We are keen to identify someone who is a self-starter and proactive and who can work effectively with a team of multidisciplinary scientists.

Responsibilities

  • Identify, evaluate, design and execute experiments for validation of novel targets in the Oncology, inflammation and immunology space
  • Collaborate with colleagues within other functions in the organization to devise plans for new target triage. Work closely with the platform group to systematically evaluate targets
  • Exploration of drug-target-phenotype relationships using chemical proteomics
  • Phenotypic in vitro assay development, data generation and analysis, and communication to scientific team and executive management.
  • Review of scientific, clinical, and patent literature to identify new target opportunities
  • Help lead strategy and planning of early-stage research programs, including identifying, evaluating, and championing new ideas and technologies
  • Help the biology team in identifying the relevant disease indications for the “targets” of interest
  • Utilize genomics-based tools for new target identification and validation
  • Develop disease relevant cellular models, using RNAi and CRISPR based tools for validating the target biology

 

Required Qualifications

    • Ph.D. with 5-8 years of experience in cell biology or related discipline with a strong publication record. 2 to 5+ years of experience in biotech/ pharmaceutical industry
    • Experience leading discovery biology efforts on project teams at various stages of the programs including target discovery/validation and lead optimization to IND-enabling studies
    • Previous work leading early discovery programs with novel target identification and validation responsibilities
    • Strong understanding of cancer cell signaling pathways and experience with target engagement, functional and phenotypic assays
    • Experience working with genomics, human genetics, and next-generation sequencing datasets, ideally in collaboration with computational teams
    • Experience in utilizing genomics-based technologies, including RNA-seq, ChIP-seq
    • Experience with gene modulation techniques in cell-based studies (RNAi, CRISPR, cDNA overexpression, etc.)
    • Experience with utilizing chemical biology tools and establishing biochemical assays is a plus
    • Ability to work effectively as an individual and as a member of multi-disciplinary project teams and present at team meetings
    • Good problem-solving skills with excellent interpersonal skills and a collaborative work style
    • Excellent written and verbal communication skills

 

All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to careers@exo-therapeutics.com

Interested in joining our team? Explore careers

Principal Scientist, Translational Biology

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

We seek a highly motivated senior level scientist with a strong background in translational and in vivo biology. This position will be an integral part of the biology group and will help drive the disease indication and biomarker studies to support the drug discovery programs towards the clinic. This is a leadership position, and the candidate will work across therapeutic areas with a primary focus in inflammation, autoimmunity and/or immuno-oncology

The individual will have some experience leading the translational biology efforts for drug discovery program/s. We are keen to identify someone who is a self-starter and proactive and who can work independently and effectively.

Responsibilities

  • Identify and validate biological contexts, in vitro and in vivo, that create a dependency on drug targets to aid indication/ context prioritization for pre-clinical studies and clinical development
  • Plan and oversee in vivo PD and efficacy studies at CRO partners to support the drug discovery program
  • Collaborate with drug discovery and biology teams to select disease indications for inflammation, autoimmune diseases and/or oncology targets and development of in vivo strategies
  • Identify combination and differentiation strategies to help identify the right patients to treat in the clinic
  • Participate in the identification and clinical translation of biomarker assays that assess drug pharmacodynamics and allow testing of preclinical response hypotheses enabling a differentiating path for drug development
  • Interpret, summarize and present research findings at internal and external scientific meetings
  • Use knowledge of inflammatory, autoimmune disease biology, and genomics data for biomarker hypotheses
  • Actively engage with clinical and research cross-functional teams to prioritize and select disease indications

Preferred Experience and Qualifications

  • Ph.D. with 5+ years of experience in biology or related discipline with a strong publication record. 2+ years in biotech/ pharmaceutical industry
  • Strong understanding of inflammation/ autoimmunity signaling pathways and experience with PK/PD/efficacy studies to validate disease indications
  • Experience driving translational biology efforts on project teams at various stages of the programs
  • Experience in utilizing genomics-based technologies, including RNA-seq and flowcytometry based assays to identify biomarkers and to understand mechanism of action is preferred
  • Experience with selection and development of in vivo disease models is preferred
  • Clear and effective verbal and written communication skills

All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to careers@exo-therapeutics.com

Interested in joining our team? Explore careers

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