Careers

Come join us!

We are a diverse group of scientists, researchers, and business leaders with the mission to develop a novel approach to medicines discovery with exosites.

At Exo, we take pride in our values:

Diversity: both in who we are and in how we think because the more perspectives we bring to a challenge, the more likely we are to succeed
Collaboration: motivated by a “speak-up culture” where divergent ideas are shared openly, respectfully, and fearlessly
Passion: a love for innovative science and commitment to excellence and creativity
Impact: tenacious drive to achieve a common goal of improving human health

Current Opportunities

Assoc Director/Director, Early Target Biology

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Overview

Exo Therapeutics seeks a strong leader to oversee our Early target biology efforts and provide strategic and technical expertise for Exo’s research portfolio. You will be an integral part of the biology leadership team and working cross functionally to drive target identification and validation. You will work closely with the bioinformatics, computational biology, Data sciences and the broad platform team to mine databases and identify new opportunities to drug exosites on targets of interest to inhibit disease relevant biology. You will have the opportunity to interface with all levels of our organization to deliver scientific excellence, as we expand the boundaries of research for patients.

Responsibilities

  • Leading a group tasked with developing and implementing strategies to identify and validate targets prior to portfolio entry across Exo’s Therapeutic Areas, including oncology, autoimmune diseases, and rare diseases
  • Work closely with the platform team to bring new targets to the portfolio with strategic value of targeting exosites for better therapeutic window or opportunities to drug intractable targets
  • Work with the other cross functional teams, including bioinformatics, biochemistry, chemical biology, screening, and chemistry to validate targets of interest for nomination into the portfolio
  • Actively mentor and develop outstanding scientists to fostering a culture of engagement and scientific rigor
  • Be accountable for devising and championing the development and application of state-of-the-art approaches for target identification alongside the bioinformatics and computational chemistry teams
  • Develop and implement technologies needed for target validation, including CRISPR/Cas9, RNA-seq, ATAC-seq, single cell RNA-seq and others as needed for validating targets of interest
  • Participate in the global scientific community through attendance at scientific conferences and publication of novel research findings in peer-reviewed, high-quality journals


Required Qualifications

  • Ph.D. with 10+ years of experience in biology, with 5+ years spent in identifying new targets for the portfolio
  • Deep expertise in oncology disease targets/pathways, understanding their relevance and identifying systems for their validation
  • Strong understanding of functional genomics approaches and its role in the target validation
  • Experience in working with bioinformatics group to mine genomics, gene expression, CRISPR and other databases for identification of new targets
  • Good understanding of development challenges/opportunities for other relevant therapeutic areas such as autoimmunity or rare diseases is a plus
  • Previous experience of effective team-leading is highly desirable.
  • Ability to successfully participate in a highly creative and enthusiastic start-up environment


All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to careers@exo-therapeutics.com.

Director, Bioinformatics

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Overview

Exo Therapeutics is seeking a Director of Bioinformatics to bring knowledge and expertise for analysis and interpretation of internal and sourced data to support Exo’s platform and drug discovery portfolio. You will be responsible for making strategic decisions, building the team, and supporting all phases of drug discovery within the organization. You will have the opportunity to drive the design and execution of experiments with key collaborators and outside contract organizations and have highly visible opportunities to interface with all levels of our organization to deliver scientific excellence, as we expand the boundaries of research for patients.

Responsibilities

  • Lead the bioinformatics efforts associated with the Discovery and research program efforts – target identification, MoA studies and biomarker discovery in support of small molecule drug discovery at Exo
  • Provide strategic, scientific, and managerial leadership to build and drive the bioinformatics group
  • Identify and implement computational methodologies and datasets needed to advance discovery and programmatic activities including analyses of gene expression data, mining of publicly available data from DEPMAP, project Achilles’ and other sources for new target discovery and validation
  • Lead the strategic efforts related to data and analysis quality using quality-control measures and collaborate on establishing data management practices
  • Developing the Bioinformatics pipeline on HCP/Cloud platforms
  • Implementing open-source Bioinformatics tools/packages, biological databases, and variant calling algorithms
  • Automating data flow, pipelines and maintaining databases for genomic data (raw and processed)


Required Qualifications

  • MS/PhD in Bioinformatics, Computational Biology, Genomics, or related discipline
  • 8+ years of relevant experience, including 4+ years of team and/or project leadership in industry or academics
  • Proven ability to manage, mentor, and develop highly productive individuals and teams
  • Hands-on experience with a broad range of current bioinformatics and computational biology tools, methods, and applications
  • Proficiency with commonly used programming languages for bioinformatics analysis, such as Python and R
  • Experience leveraging data from large-scale, open repositories and integrating datasets
  • Experience with high performance computing and cloud computing platforms
  • Ability to effectively collaborate in a fast-paced, dynamic environment
  • Ability to successfully participate in a highly creative and enthusiastic start-up environment


All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to careers@exo-therapeutics.com.

Director/Senior Director, Data Sciences

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSight™ platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Overview

Exo Therapeutics seeks a highly motivated Director or Senior Director with a strong background in data sciences and architecture to serve as a key part of Exo’s efforts to advance our pipeline of drug discovery programs. You will be a key member of our platform technology group who will oversee data science needs across our entire discovery organization from novel targets to clinical enabling studies. As a leader in the discipline, you will work closely with our Head of Platform to build a data sciences team capable of supporting the data needs of a growing biotech. Your effort will help us progress our multi-disciplinary programs to deliver on the extraordinary promise of exosite-targeted therapeutics.

We are seeking a veteran data scientist with a combination of computational and scientific skills to establish a global strategy for data handling, including collecting, storing, analyzing, and visualizing data and then work with cross-functional teams to build the vision. This position will be part of the platform team, working alongside biologists, chemists, and computational scientists who generate and use the data. The role provides an exciting opportunity in a startup environment to build a future-ready team capable of handling diverse data streams. Your contributions will have a direct impact on the future development of the ExoSight™ platform.

Responsibilities

  • Establish a complete strategy for data handling across the company’s discovery organization including a design for the architecture of the data, the infrastructure required to maintain those data, and the people who can deliver those systems
  • Collaborate with other scientific teams to improve data collection, reduce “knowledge friction”, and help the organization establish good data practices
  • Create solutions for proprietary data including biochemical and cell data, protein structure data, and multi-omics data and assist in the mining of public data sources
  • Manage and develop the team tasked with delivering data solutions for the company
  • Create insight into diseases of unmet need by working across the organization to process proprietary and public data sets and create from generation to intake to visualization
  • Be a key voice in the direction and evolution of the ExoSight™ technology platform that helps identify novel targets and applications


Preferred Experience and Qualifications

  • Advanced degree in Computer Science, Analytics, or similar discipline with 10+ years experience in life sciences or an advanced degree in a life sciences field with 10+ years experience in the data sciences
  • Track record of success in the establishment and maintenance of data or analytic pipelines and managing the underlying infrastructure required to secure those pipelines
  • Strong understanding of how data sciences and architecture enable pre-clinical discovery research
  • Experience working with the data flows common to pre-clinical drug discovery research, especially in how those data flows are visualized, secured, searched, and archived
  • Managerial experience with success in the mentorship and development of junior scientists, engineers, or programmers
  • Strong interpersonal skills and ability to communicate complex concepts to stake holders with wide range of expertise.


All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to careers@exo-therapeutics.com.

Director, Translational Biology

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Exo Therapeutics seeks a strong leader to oversee our translational biology efforts and provide strategic and technical expertise for Exo’s research portfolio. You will be an integral part of the biology leadership team, working cross functionally to drive cutting-edge research for disease indications and biomarker studies – with an initial focus in immunology and/or oncology. You will be responsible for making decisions, but also be comfortable rolling up your sleeves and contributing hands-on with the team. You will have the opportunity to drive the design and execution of experiments with key collaborators and outside contract organizations and have highly visible opportunities to interface with all levels of our organization to deliver scientific excellence, as we expand the boundaries of research for patients.

Responsibilities

  • Provide strategic, scientific, and managerial leadership to build and drive the translational biology efforts
  • Oversee identification and validation of biological contexts, in vitro and in vivo, that create a dependency of drug targets to aid indication/ context prioritization for pre-clinical studies and clinical development
  • Define, oversee, and lead biomarker strategy to enable progression from preclinical to clinical studies in collaboration with colleagues in research, clinical development, and clinical operations departments
  • Develop program specific translational strategies that integrate preclinical research findings
  • Serve as translational lead (directly and/or indirectly) for multidisciplinary drug discovery project teams in a fast-paced, results-driven biotech environment
  • Collaborate with drug discovery and clinical teams to select disease indications and combination strategies for inflammation and/or oncology targets
  • Define biomarker assays that assess drug pharmacodynamics and allow testing of preclinical response hypotheses enabling a differentiating path for drug development
  • Manage relationships with external KOLs aimed at gaining better understanding of patient stratification, combination studies and PD biomarkers


Required Qualifications

  • Ph.D. with 10+ years of experience in biology, with 7+ years in biotech/ pharmaceutical industry
  • Experience leading translational biology efforts on project teams at various stages of the programs
  • Strong understanding of inflammation/ autoimmunity/ cancer cell signaling pathways and experience with PK/PD/efficacy studies to validate disease indications
  • A strong track record of success in delivering clinical candidates
  • Experience with Small molecule drug development and IND submissions
  • Experience with selection and development of in vivo disease models
  • Ability to successfully participate in a highly creative and enthusiastic start-up environment


All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to careers@exo-therapeutics.com.

Principal Scientist, Biochemistry

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a privately held small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Overview

Exo Therapeutics seeks a highly motivated Principal Scientist with a strong background in biochemistry to serve as a key part of Exo’s efforts to advance our pipeline of drug discovery programs. You will work at a critical juncture of medicinal chemistry and biology with opportunities to contribute to the development of biochemical assays, establishment of small molecule profiling cascades, and the strategic development of Exo’s biochemistry group. Your effort will help us progress our multi-disciplinary programs to deliver on the extraordinary promise of exosite-targeted therapeutics.

As Principal Scientist in Biochemistry, you will help shape the company’s drug discovery pipeline by designing, building, and operating a compound profiling assay cascade for one or more small molecule programs in oncology or inflammation. Exosites are unique protein pockets which require diligence and creativity to fully understand, and you will be a key part of our efforts to do so. We are keen to identify a proactive self-starter of outstanding potential with the technical and collaboration skills to set and achieve a vision of success for our frontline research efforts. As part of a rapidly growing, early-stage company you will have a substantial contribution to build-out and maintenance of our growing laboratory space.

Responsibilities

  • Propose biochemical assays for exosites ranging from validation studies in novel targets to proof-of-mechanism studies in advanced programs, then collaborate closely with medical chemistry, chemical biology, protein expression, and biology groups to establish and deliver those assays
  • Be an expert in effective and efficient screening strategies and guide project teams to assay cascades that best suit the needs of their project
  • Be a leader to a project team and a mentor to our growing scientific staff
  • Help guide the company’s growing biochemistry capabilities as we expand our laboratory footprint
  • Contribute your expertise and perspective to ideating new programs and contribute to the advancement of our ExoSight™ technology platform


Required Qualifications

  • Ph.D. in biochemistry, chemical biology, or related discipline and 8+ years of industrial experience; BS/MS candidates with 14+ years of experience are also welcomed to apply
  • Proficient in mechanistic biochemistry, particularly novel biochemical assay development
  • Expert in the strategy of building assay cascades for the characterization of small molecule therapeutics
  • Excellent communicator with a collaborative mindset
  • Success in the management, development, and mentoring of less experienced scientists, ideally across functions
  • Expertise in screening adjacent areas such as automation, HTS processes, and assay miniaturization is a plus
  • Experience in oncology or inflammatory diseases is a plus


All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to careers@exo-therapeutics.com.

Principal Scientist, Translational Biology

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

We seek a highly motivated senior level scientist with a strong background in translational and in vivo biology. This position will be an integral part of the biology group and will help drive the disease indication and biomarker studies to support the drug discovery programs towards the clinic. This is a leadership position, and the candidate will work across therapeutic areas with a primary focus in inflammation, autoimmunity and/or immuno-oncology

The individual will have some experience leading the translational biology efforts for drug discovery program/s. We are keen to identify someone who is a self-starter and proactive and who can work independently and effectively.

Responsibilities

  • Identify and validate biological contexts, in vitro and in vivo, that create a dependency on drug targets to aid indication/ context prioritization for pre-clinical studies and clinical development
  • Plan and oversee in vivo PD and efficacy studies at CRO partners to support the drug discovery program
  • Collaborate with drug discovery and biology teams to select disease indications for inflammation, autoimmune diseases and/or oncology targets and development of in vivo strategies
  • Identify combination and differentiation strategies to help identify the right patients to treat in the clinic
  • Participate in the identification and clinical translation of biomarker assays that assess drug pharmacodynamics and allow testing of preclinical response hypotheses enabling a differentiating path for drug development
  • Interpret, summarize and present research findings at internal and external scientific meetings
  • Use knowledge of inflammatory, autoimmune disease biology, and genomics data for biomarker hypotheses
  • Actively engage with clinical and research cross-functional teams to prioritize and select disease indications


Preferred Experience and Qualifications

  • Ph.D. with 5+ years of experience in biology or related discipline with a strong publication record. 2+ years in biotech/ pharmaceutical industry
  • Strong understanding of inflammation/ autoimmunity signaling pathways and experience with PK/PD/efficacy studies to validate disease indications
  • Experience driving translational biology efforts on project teams at various stages of the programs
  • Experience in utilizing genomics-based technologies, including RNA-seq and flowcytometry based assays to identify biomarkers and to understand mechanism of action is preferred
  • Experience with selection and development of in vivo disease models is preferred
  • Clear and effective verbal and written communication skills


All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to careers@exo-therapeutics.com

Scientist, Biochemistry

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a privately held small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Overview

Exo Therapeutics seeks a highly motivated Scientist with training in biochemistry to serve as a key part of Exo’s efforts to advance our pipeline of drug discovery programs. You will work at a critical juncture of medicinal chemistry and biology with opportunities to contribute to the development of biochemical assays, establishment of small molecule profiling cascades, and the strategic development of Exo’s biochemistry group. Your effort will help us progress our multi-disciplinary programs to deliver on the extraordinary promise of exosite-targeted therapeutics.

As Scientist in Biochemistry, you will help advance the company’s drug discovery pipeline by building and operating a compound profiling assay cascade for one or more small molecule programs in oncology or inflammation. Exosites are unique protein pockets which require diligence and creativity to fully understand, and you will be a key part of our efforts to do so. We are keen to develop a scientist with high potential with the technical and collaboration skills to achieve success for our frontline research efforts. You will have the opportunity to make substantial contributions to our rapidly growing, early-stage company.

Responsibilities

  • Develop and validate biochemical assays for exosite projects from early target identification to on-going program needs including small molecule profiling and target mechanism studies
  • Collaborate closely with a cross-functional project team – particularly medicinal and computational chemistry as well as chemical and structural biology – to develop and advance small molecule therapeutics programs
  • Use your lab-based biochemistry skills to build your team’s understanding of small molecules that target exosites
  • Contribute your expertise and perspective to ideating new programs and contribute to the advancement of our ExoSight technology platform


Required Qualifications

  • Ph.D. in biochemistry, chemical biology, or related discipline or a BS/MS with 6+ years of related experience
  • Research experience in the techniques used to understand enzyme function and behavior, especially those associated with enzyme/small molecule interactions
  • Development experience with common binding assay techniques (e.g. fluorescence polarization, TR-FRET, AlphaScreen, etc.) and/or activity assay techniques (e.g. enzyme kinetics, reporter assays, etc) including data handling and analysis
  • Excellent communicator and team player with an interest in cross-functional research
  • Experience in oncology or inflammatory diseases is a plus


All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to careers@exo-therapeutics.com.

Exo Therapeutics is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets.