A new discovery paradigm to unlock intractable drug targets with exosites

Our Approach

divider-tri-color
Exo Therapeutics is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.
diagram-exosight-platform

Team

divider-tri-color
MichaelBruce-GRAY
ChristopherLiu-GRAY
PaulSchneider-GRAY
GhotasEvindar-GRAY
ShilpiArora-GRAY
DavidLiu-GRAY
AlanSaghatelian-GRAY
JPMaianti-GRAY
StuartSchreiber-GRAY
BenjaminEbert-GRAY
BenjaminCravatt-GRAY
CharlesRobert-GRAY
MichaelBruce-GRAY
AaronNelson-GRAY
TomCahill-GRAY
NageshMahanthappa-GRAY

Careers

divider-white-v2
Current Opportunities

Senior/Principal Research Associate, Biochemistry

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Overview

Exo Therapeutics seeks a highly motivated Senior/Principal Research Associate with a strong background in biochemistry assay implementation and contributing to a multidisciplinary team in external and internal drug discovery activities. This position will be an integral part of the biochemistry team and will help drive the drug discovery programs forward. You will work across therapeutic functions with a primary focus in discovery and development of therapeutics in oncology, autoimmune and immuno-inflammation.

The senior/principal research associate will be expected to contribute to and complement our existing technical expertise to enhance and accelerate research. We are keen to identify someone who is a self-starter and proactive and who can work independently and effectively, both with the Exo team and external collaborators. The candidate will also participate in the build-out and maintenance of our growing laboratory environment.

Responsibilities

  • Perform routine biochemical screening of compounds, eg IC50, in house or in collaboration with external partners.
  • Communication and discussion of results with internal project teams, especially chemistry and biology.
  • Development of novel screening assays for use either in-house or for transfer to CRO’s.
  • Coordination of assay workflow locally and/or with the CRO partners, data analysis and presentation of results to the internal and external teams.
  • Employ biochemical and biophysical methods enabling mechanistic studies to determine the mode-of-inhibition for promising hits.
  • Propose and implement new experimental techniques and troubleshoot roadblocks in collaboration with the team.
  • Independently manage and order supplies/reagents in a timely manner to ensure continuous progress of parallel experimental workflows under your responsibility.
  • Management of laboratory equipment, including maintenance, vendor relations and service contracts.
  • Maintain good data records, protocols, and summaries. Analyze raw data and interpret integrated datasets using Prism, Vortex, or similar software packages.
  • Use of electronic lab notebook and data registration to corporate database. 
  • Take all opportunities to make intellectual contributions and discoveries.

Required Qualifications

  • Bachelor’s degree in a life sciences-related field with by a proven track-record of hands-on laboratory experience for 4-6 years, or a Master’s degree with 4+ years of research experience, respectively.
  • Strong foundation with a background in small molecule discovery/validation, biochemistry and biophysical methods.
  • Proficiency in experimental design and data analysis using Graphpad Prism, Excel or equivalent software.
  • Troubleshooting skills, analytical perseverance, with a strong ability to integrate advice.
  • Proficiency in results presentation, data documentation, and scientific communication.
  • Analyze, interpret, and effectively present scientific data at team meetings
  • Ability to work effectively with flexible supervision as a member of multiple project teams
  • Prior experience working with CRO partners highly preferred
  • Good problem-solving skills with excellent interpersonal skills and a collaborative work style

Desired technical competencies:

  • Assay development experience and capabilities such as FP, TR-FRET, AlphaScreen, etc.
  • Experience in mechanistic enzymology such as Ki, mode-of-inhibition, kinetics, etc.

Other complementary and transferable skills:

  • Molecular biology, protein expression, purification and characterization (for example: M/S, SEC, DLS, CD, SDS-PAGE, etc.
  • Working knowledge of biophysical methods such as SPR, MST, ITC, DSF, etc.
  • Familiarity with Cell-based assays (for example: BRET, iLite, DualGlo, CTGlo, HiBiT, CaspaseGlo, etc.)

All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to careers@exo-therapeutics.com

Senior Scientist, Medicinal Chemist, Chemical Biology, Biochemistry

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Exo Therapeutics seeks a highly motivated senior scientist with a strong background in synthetic medicinal chemistry, or chemical biology. You will be responsible for structural evaluation of protein constructs, tool and probe design, establishing new biochemical assay for validating exosite across therapeutic targets. You will work across a multidisciplinary team contributing to early target identification and progression of established programs across Exo portfolio.

As a senior scientist, you will be expected to contribute and complement our existing technical expertise at a critical stage of the company’s platform: identifying and validating novel exosites that will deliver extraordinary therapeutic opportunities. We are keen to identify a proactive self-starter and who is comfortable with independent research as well as effective teamwork, both with the Exo team and external collaborators. The candidate will also participate in the build-out and maintenance of our growing laboratory space.

Responsibilities

• Evaluate target proteins across the human proteome, propose new biochemical/biophysical assays, and deliver tools and probes to enable those assays.
• Enable new screening methods across the Exo portfolio.
• Support biochemical/biophysical assay and screening of compounds, eg IC50, in house or in collaboration with external partners.
• Work collaboratively with medicinal chemistry, computational chemistry, biochemistry and cell biology groups to deliver compelling drug discovery programs.
• Communicate and discuss results with internal project team members across multiple disciplines.
• Maintain good data records, protocols, and summaries. Analyze raw data and interpret integrated datasets using Prism, Vortex, or similar software packages

Required Qualifications

• Ph.D. in medicinal chemistry, chemical biology or related discipline with postdoctoral training and a proven track-record with 3+ years of industrial experience.
• Strong track record in novel biochemical assay development, use of small molecule probes in target discovery/validation, and biochemistry and biophysical method development.
• Experience with structural biology, computational chemistry, protein homology modeling.
• Proficiency in results presentation, data documentation, and written and oral communication.
• Foster teamwork in a collaborative environment.

All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to careers@exo-therapeutics.com

Interested in joining our team? Explore careers

Associate Director/Director, Chemical Biology

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Exo Therapeutics seeks a highly motivated Associate Director or Director-level candidate with a strong background in chemical biology to serve as a key part of Exo’s efforts to build an engine that can identify and validate exosites across the human proteome. You will work at a critical juncture of disciplines with opportunities to contribute to the structural evaluation of protein constructs, the design of tool and probe molecules, and the establishment of new biochemical assays for mechanism of action studies. You will then use that knowledge to work with a multidisciplinary team to build drug discovery programs that will deliver on the extraordinary promise of exosite-targeted therapeutics.

As the Associate Director/Director of Chemical Biology, you will help shape the company’s early target discovery strategy and guide the development of a team to assist you in this role. We are keen to identify a proactive self-starter of outstanding potential with the technical skills to set a vision of success and the collaboration skills to lead a team there, both with Exo staff as well as with external collaborators. As part of a rapidly growing, early-stage company you will also participate in the build-out and maintenance of our growing laboratory space.

Responsibilities

• Help us identify novel exosites: evaluate target proteins across the human proteome, propose new biochemical/biophysical assays, and deliver tools and probes to enable those assays
• Collaborate closely with Biochemistry to establish cutting-edge assay capabilities
• Serve as a key leader in a discovery team tasked with delivering compelling drug discovery programs
• Build and develop a team of talented scientists to support the company’s growing needs in chemical biology
• Contribute your expertise and perspective to the strategic direction of the company’s early target ID platform

Required Qualifications

• Ph.D. in chemical biology, biochemistry, or related discipline and 6+ years of industrial experience
• Proficiency in target discovery and validation sciences, particularly in the development and use of molecular probes
• Experience in the development of biochemical and biophysical methods for protein characterization is a plus
• Other skills that could contribute to your success include experience with structural biology, computational chemistry, or medicinal chemistry
• Excellent communicator with a collaborative mindset who can represent the Chemical Biology function to internal and external stakeholders
• The ability to motivate and develop a team to its highest potential
• A strategic thinker who is sensitive to the balance between project goals and portfolio goals with vision to define long-term success

All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to careers@exo-therapeutics.com

Senior Research Associate, Biology

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Exo Therapeutics seeks a highly motivated biologist with a strong background in cell/molecular biology. This position will be an integral part of the biology group and the ideal candidate will help drive discovery of novel therapeutics across disease areas with a primary focus in oncology. This is predominantly a laboratory/wet bench-based role and requires strong experimental technique, ability to deliver quality data in a timely manner, and work effectively with team members in support of small molecule drug discovery efforts. Data analysis, interpretation, documentation and presentation skills is required.

Responsibilities

Key responsibilities of this role include, but are not limited to:

    • Design, execute and perform data analysis for cell-based experiments.
    • Develop and execute plate-based cellular assays in medium- to high- throughput (96/384 well) assay formats utilizing small molecules to generate full dose response curves.
    • Independently perform in vitro biological assays including viability assays (2D, clonogenic), western blotting and apoptosis assays.
    • Perform molecular techniques including DNA/RNA isolation, cloning, PCR, qRT-PCR, gene expression analysis.
    • Generate and maintain stable cell lines.
    • Utilize compounds and genetic tools (siRNA/shRNA/CRISPR) to dissect target function in relevant cell models.
    • Execute studies to understand mechanism-of-action of compounds and/or genetic perturbations.
    • Interact and collaborate with biology and chemistry team members to contribute to drug discovery and development program progression, present data at regular team meetings.
    • Willingness to learn while actively contributing to progress of the projects in a fast-paced environment.
    • Interpret, compile and document experimental data; manage laboratory notebook, databases, and/or spreadsheets to present data in a meaningful manner.

Required Qualifications

  • BS/MS degree in biological sciences, with at least 2+ years of hands-on experience in cell/molecular biology/cancer biology discipline, preferably in industry setting. We are seeking candidates with significant proven technical expertise in cell biology in application to drug discovery.

Experienced in: 

  • Aseptic mammalian tissue culture, cell line growth and maintenance.
  • In vitro viability assays (2D growth, clonogenic) in low-medium throughput format.
  • Prior knowledge with preparing compound dilutions, dosing, generation, and interpretation of full dose response curves is desirable.
  • Protein lysate preparation from cells and tissues, and quantitative Western blotting.
  • Cell and molecular techniques including DNA/RNA isolation, cloning, and PCR/ qRT-PCR. Flow cytometry/FACS experience is a plus.
  • Cell based assay development and execution (96/384 well) using a variety of readout technologies (e.g. fluorescence, luminescence).
  • Working with genetic tools (siRNA/shRNA), transfection, transduction and stable cell line generation.
  • Experience using Microsoft Excel and GraphPad Prism is desirable.
  • Ability to work as a team player and be able to work on several projects simultaneously.
  • Understanding of cancer biology and/or immunology is desirable.

All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to careers@exo-therapeutics.com

Interested in joining our team? Explore careers

©2021 Exo Therapeutics, Inc.