A new discovery paradigm to unlock intractable drug targets with exosites

Our Approach

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Exo Therapeutics is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.
diagram-exosight-platform

Team

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Michael Bruce, PhD​
CEO
Formerly: CRISPR, Pfizer, Kaleido, Millennium​
Ghotas Evindar, PhD
Executive Director,
Drug Discovery
Shilpi Arora, PhD
Executive Director,
Head of Biology
Paul Schneider
Senior Vice President, Finance & Operations
JP Maianti, PhD
Co-Founder
Harvard Chemistry & Chemical Biology
C&EN Talented 12 award, Canada Academic Gold Medal
David Liu, PhD
Co-Founder
Broad, HHMI
Founder, Editas, Beam, Prime
Richard Merkin Professor, Director of the Merkin Institute, Core Institute Member, and Vice-Chair of the Faculty, Broad Institute
Investigator, Howard Hughes Medical Institute
Thomas Dudley Cabot Professor of the Natural Sciences and Professor of Chemistry & Chemical Biology, Harvard University
Alan Saghatelian, PhD
Co-Founder
Salk Institute
Professor, Salk Institute
Clayton Foundation Laboratories for Peptide Biology
Dr. Frederik Paulsen Chair
JP Maianti, PhD
Co-Founder
Harvard Chemistry & Chemical Biology
C&EN Talented 12 award, Canada Academic Gold Medal
Stuart Schreiber, PhD

SAB Member

Broad

Core Institute Member, Broad Institute

Morris Loeb Professor of Chemistry and Chemical Biology, Harvard University
Investigator, Howard Hughes Medical Institute
Benjamin Ebert, MD, PhD

SAB Member

DFCI, HHMI
George P. Canellos, MD, and Jean S. Canellos Professor of Medicine

Harvard Medical School
Chair of Medical Oncology, Dana-Farber Cancer Institute

Benjamin Cravatt, PhD

SAB Member

Scripps
Gilula Chair of Chemical Biology Professor
Michael Bruce, PhD​

CEO

Aaron Nelson, MD, PhD
Novartis Venture Fund
Tom Cahill, MD, PhD
Newpath Partners

Careers

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Current Opportunities

Senior/Principal Research Associate, Biochemistry

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Overview

Exo Therapeutics seeks a highly motivated Senior/Principal Research Associate with a strong background in biochemistry assay implementation and contributing to a multidisciplinary team in external and internal drug discovery activities. This position will be an integral part of the biochemistry team and will help drive the drug discovery programs forward. You will work across therapeutic functions with a primary focus in discovery and development of therapeutics in oncology, autoimmune and immuno-inflammation.

The senior/principal research associate will be expected to contribute to and complement our existing technical expertise to enhance and accelerate research. We are keen to identify someone who is a self-starter and proactive and who can work independently and effectively, both with the Exo team and external collaborators. The candidate will also participate in the build-out and maintenance of our growing laboratory environment.

Responsibilities

  • Perform routine biochemical screening of compounds, eg IC50, in house or in collaboration with external partners.
  • Communication and discussion of results with internal project teams, especially chemistry and biology.
  • Development of novel screening assays for use either in-house or for transfer to CRO’s.
  • Coordination of assay workflow locally and/or with the CRO partners, data analysis and presentation of results to the internal and external teams.
  • Employ biochemical and biophysical methods enabling mechanistic studies to determine the mode-of-inhibition for promising hits.
  • Propose and implement new experimental techniques and troubleshoot roadblocks in collaboration with the team.
  • Independently manage and order supplies/reagents in a timely manner to ensure continuous progress of parallel experimental workflows under your responsibility.
  • Management of laboratory equipment, including maintenance, vendor relations and service contracts.
  • Maintain good data records, protocols, and summaries. Analyze raw data and interpret integrated datasets using Prism, Vortex, or similar software packages.
  • Use of electronic lab notebook and data registration to corporate database. 
  • Take all opportunities to make intellectual contributions and discoveries.

Required Qualifications

  • Bachelor’s degree in a life sciences-related field with by a proven track-record of hands-on laboratory experience for 4-6 years, or a Master’s degree with 4+ years of research experience, respectively.
  • Strong foundation with a background in small molecule discovery/validation, biochemistry and biophysical methods.
  • Proficiency in experimental design and data analysis using Graphpad Prism, Excel or equivalent software.
  • Troubleshooting skills, analytical perseverance, with a strong ability to integrate advice.
  • Proficiency in results presentation, data documentation, and scientific communication.
  • Analyze, interpret, and effectively present scientific data at team meetings
  • Ability to work effectively with flexible supervision as a member of multiple project teams
  • Prior experience working with CRO partners highly preferred
  • Good problem-solving skills with excellent interpersonal skills and a collaborative work style

Desired technical competencies:

  • Assay development experience and capabilities such as FP, TR-FRET, AlphaScreen, etc.
  • Experience in mechanistic enzymology such as Ki, mode-of-inhibition, kinetics, etc.

Other complementary and transferable skills:

  • Molecular biology, protein expression, purification and characterization (for example: M/S, SEC, DLS, CD, SDS-PAGE, etc.
  • Working knowledge of biophysical methods such as SPR, MST, ITC, DSF, etc.
  • Familiarity with Cell-based assays (for example: BRET, iLite, DualGlo, CTGlo, HiBiT, CaspaseGlo, etc.)

All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to careers@exo-therapeutics.com

Scientist, Biochemistry

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Exo Therapeutics seeks a highly motivated research scientist with a strong background and training in biochemistry assay implementation and contributing to a multidisciplinary team in external and internal drug discovery activities. This position will be an integral part of the biochemistry team and will help drive the drug discovery programs forward. The individual will work across therapeutic functions with a primary focus in discovery and development of therapeutics in oncology, autoimmune and immuno-inflammation.

The research scientist is expected to propose and establish new biochemical assays and contribute to existing technical expertise to enhance and accelerate Exo research programs. We are keen to identify someone who is driven, self-starter and proactive. The individual will need to work independently and effectively, both with the Exo team and external collaborators. The candidate will also participate in the build-out and maintenance of our growing laboratory environment.

Responsibilities

  • Perform routine biochemical screening of compounds, eg IC50, in house or in collaboration with external partners.
  • Communication and discussion of results with internal project teams, especially chemistry and biology.
  • Coordination of assay workflow locally and/or with the CRO partners, data analysis and presentation of results to the internal and external teams.
  • Employ biochemical and biophysical methods enabling mechanistic studies to determine the mode-of-inhibition for promising hits.
  • Propose and implement new experimental techniques and troubleshoot roadblocks in collaboration with the team.
  • Independently manage and order supplies/reagents in a timely manner to ensure continuous progress of parallel experimental workflows under your responsibility.
  • Management of laboratory equipment, including maintenance, vendor relations and service contracts.
  • Maintain good data records, protocols, and summaries. Analyze raw data and interpret integrated datasets using Prism, Vortex, or similar software packages.
  • Use of electronic lab notebook and data registration to corporate database.
  • Take all opportunities to make intellectual contributions and discoveries.

 Required Qualifications

  • PhD in biochemistry or a life sciences-related field with a proven track-record with postdoctoral research experience.
  • Strong foundation with a background in small molecule discovery/validation, biochemistry and biophysical methods.
  • Track record of design and implementation of biochemical assays for compound profile and mechanist studies.
  • Proficiency in experimental design and data analysis using Graphpad Prism, Excel or equivalent software.
  • Troubleshooting skills, analytical perseverance, with a strong ability to integrate advice.
  • Proficiency in results presentation, data documentation, and scientific communication.
  • Analyze, interpret, and effectively present scientific data at team meetings
  • Ability to work effectively and independently as a member of multiple project teams
  • Good problem-solving skills with excellent interpersonal skills and a collaborative work style

Desired technical competencies:

  • Assay development experience and capabilities such as FP, TR-FRET, AlphaScreen, etc.
  • Experience in mechanistic enzymology such as Ki, mode-of-inhibition, kinetics, etc.

 Other complementary and transferable skills:

  • Molecular biology, protein expression, purification and characterization (for example: M/S, SEC, DLS, CD, SDS-PAGE,
  • Working knowledge of biophysical methods such as SPR, MST, ITC, DSF, etc.
  • Familiarity with Cell-based assays (for example: BRET, iLite, DualGlo, CTGlo, HiBiT, CaspaseGlo, et

All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to careers@exo-therapeutics.com

Interested in joining our team? Explore careers

Scientist, Chemical Biology

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Exo Therapeutics seeks a highly motivated Scientist with a strong background in chemical biology to work on internal target identification and drug discovery. The candidate will be responsible for tools and probes design, novel biochemical assay establishment and execution of mechanistic experiments. The desired candidate will work across a multidisciplinary team contributing to early target identification and progression of established programs across Exo portfolio.

The scientist will be expected to contribute and complement our existing technical expertise to enhance and accelerate drug discovery. We are keen to identify someone who is a self-starter and proactive and who can work independently and effectively, both with the Exo team and external collaborators. The candidate will also participate in the build-out and maintenance of our growing laboratory space.

Responsibilities

  • Identification of protein targets, their biological pathway and mechanistic evaluation, proposal of tool and probes for biochemical assay development for cellular target validation.
  • Development and application of biochemical, biophysical, and genetic methods for target-ligand engagement and validation in cell models.
  • Propose and develop necessary biochemical assay and screening of compounds, eg IC50, in house or in collaboration with external partners.
  • Work collaboratively with chemistry, computational chemistry, biochemistry and cell biology groups to drive the drug discovery programs forward.
  • Communication and discussion of results with internal project team members across multiple disciplines.
  • Coordination of assay workflow locally and/or with the CRO partners, data analysis and presentation of results in a team setting.
  • Employ biochemical and biophysical methods enabling mechanistic studies to determine the mode-of-inhibition for promising hits.
  • Management of laboratory equipment, including maintenance, vendor relations and service contracts.
  • Maintain good data records, protocols, and summaries. Analyze raw data and interpret integrated datasets using Prism, Vortex, or similar software packages.

 

Required Qualifications

  • D. in chemical biology or related discipline with a proven track-record and hands-on laboratory experience.
  • Strong foundation and hands on experience in novel biochemical assay development, use of small molecule probes in target discovery/validation, biochemistry and biophysical method development.
  • Track record of proposal, design, development, and execution of biological hypotheses and evaluation.
  • Solid understanding of structural biology, systems biology, and molecular biology
  • Excellent skillsets in appropriate programing languages, computational tools, data manipulation and visualization.
  • Experience with structural biology, computational chemistry, protein homology modeling.
  • Proficiency in experimental design and data analysis using Graphpad Prism, Excel or equivalent software.
  • Proficiency in results presentation, data documentation, and written and oral communication.
  • Work independently as apart of dynamic team of scientists with diverse expertise.
  • Foster teamwork in a collaborative environment.

Other complementary and transferable skills:

  • Protein expression, purification and characterization (for example: M/S, SEC, DLS, CD, SDS-PAGE,
  • Working knowledge of biophysical methods such as SPR, MST, ITC, DSF, etc.
  • Familiarity with Cell-based assays (for example: BRET, iLite, DualGlo, CTGlo, HiBiT, CaspaseGlo, etc.)

All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to careers@exo-therapeutics.com

Interested in joining our team? Explore careers

Senior/Principal Scientist, Medicinal Chemistry

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Exo Therapeutics is seeking a Senior/Principal Scientist, Medicinal Chemistry with 5+ years of experience who will be responsible for designing and synthesis proposal for molecular targets of interest at hit to lead and lead optimization stage of the program in collaboration with drug discovery team and external partners. This position will provide a multiple disciplinary collaboration with internal scientists and collaboration and oversight of external synthetic and medicinal chemistry resources to advance small molecule drug discovery projects to critical decision-making milestones – from target validation, hit identification to clinical candidate selection. The qualified candidate will be responsible for formulating and executing the project chemistry strategy, contributing to the medicinal chemistry scientific excellence, fostering innovation and cross-functional collaboration with both the internal and external scientific community.

Responsibilities

  • Deliver project milestones on a timely fashion by leading chemistry efforts through good scientific judgement and smooth project execution in collaboration with cross functional research team.
  • Contribute to medicinal chemistry and program strategy and vision.
  • Analyze screening data, establish SAR, perform literature reviews, design, propose, and execute medicinal chemistry plans, coordinate chemistry and biology data to support compound progression and patent strategies.
  • Supervise and direct synthetic chemistry activities at contract research organizations (CROs).
  • Engage in evaluating and implementing enabling discovery technology, including different modalities for drug discovery.
  • Represent and promote the company externally.

Required Qualifications

  • Ph.D. in organic chemistry or medicinal chemistry
  • Minimum 5 years of industry experience in biotech or pharmaceutical setting
  • Expert knowledge of modern methods of synthetic and medicinal chemistry is required
  • Molecular modeling capabilities and structure-based drug discovery experience is preferred.
  • Experience as a project leader in the biopharmaceutical industry is preferred
  • Ability to collaborate with internal/external matrix team members (e.g. chemistry, lead discovery, bioinformatics, etc.)
  • Experience in one or more therapeutic areas/target classes is preferred
  • Experience working with CRO partners highly preferred
  • Good understanding of biochemical and biophysical methods and data and PK/PD data analysis and modeling
  • Ability to multi-task and manage multiple projects and priorities at one time
  • Ability to work effectively as an individual and as a member of multi-disciplinary project teams
  • Analyze, interpret, and effectively present scientific data at team meetings
  • Excellent written and verbal communication skills
  • Good problem-solving skills
  • Self-motivated, proactive, curious, hard-working
  • Excellent interpersonal skills and a collaborative work style
  • Outgoing personality and a team player

All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to careers@exo-therapeutics.com

Associate Director/Director, Computational Chemistry

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Exo Therapeutics is seeking an Associate Director/Director of Computational Chemistry with 8+ years of experience in the relevant field to support Exo’s drug discovery programs. The individual will need to be enthusiastic and visionary to support Exo’s drug discovery modeling needs and to evolve both ExoSightTM and internal DNA encoded chemical library platforms in a multi-disciplinary team setting. The qualified candidate will work within a matrixed and dynamic team to applying their computational chemistry, molecular modeling, cheminformatics, and bioinformatic techniques to advance small-molecule drug discovery programs while building and leading Exo’s internal computational team and capacities. This position requires great initiative and a curiosity to explore new endeavors in platform development and drug discovery computational skillsets and problem-solving capabilities that will foster innovation and cross-functional collaboration with both the internal and external scientific community.

Responsibilities

  • Application of structure-based drug design methods and modeling skillsets to support ongoing programs
  • Close collaboration and teamwork with discovery scientists in support of medicinal chemistry programs
  • Support design of lead molecules and contribute to intellectual properties and IP generation
  • Development of cheminformatics algorithms to enable both DNA encoded libraries (DELs) and ExoSightTM platform development
  • Support in silico design and cheminformatic techniques in development of DEL collection
  • Develop novel machine learning (ML) algorithms in support of DEL screening output
  • Capable of advanced computational techniques including compound design, pharmacophore modeling, molecular docking, protein alignment, protein prediction models, library design, diversity analysis, and high throughput data analysis
  • Identify and implement new computational chemistry and molecular modeling methods and their application in the drug discovery and development process
  • A thought leader to support and establish Exo’s computational team and capacities

 

Required Qualifications

  • PhD. in computational chemistry, biophysics, or related discipline with at least 8+ years of relevant experience
  • Extensive experience and use of modeling software such as Schrödinger, MOE, PyMOL in structure-based drug design
  • Expertise in structural biology, protein homology studies, and molecular dynamic simulations
  • Excellent track record of in silico techniques and establishing docking models to support medicinal chemistry effort
  • A comprehensive understanding of data mining and visualization, ligand and structure-based design, conformational analysis, and pharmacophore optimization
  • Demonstrated understanding of all aspects of modern drug discovery including medicinal chemistry, DMPK principles and multi-parameter optimization
  • Excellent interpersonal and communication skills with solid written and verbal skill sets
  • Solid scientific track record supported by peer-reviewed publications and patents
  • Have a strategic vision of his/her field and build Exo’s internal computational modeling capabilities
  • Demonstrated leadership skills with initiative and drive to enable novel capabilities
  • Strong and energetic team player who strives toward an environment with collaboration and open culture.
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All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to careers@exo-therapeutics.com

Interested in joining our team? Explore careers

Senior/Principal Scientist, Target ID & Validation

About the company

Exo Therapeutics (https://exo-therapeutics.com/) is a small molecule drug discovery and development company with a pioneering technology to address intractable pharmaceutical targets. By leveraging the company’s ExoSightTM platform, Exo is developing a deep pipeline of potent drug candidates that bind exosites, distal and unique binding pockets that have the potential to reprogram enzyme activity for precise and robust therapeutic effect. Through this specific and selective approach to challenging targets, the company’s team of world-class researchers is unlocking breakthrough therapeutics in oncology, inflammation and a broad range of other diseases.

Exo Therapeutics seeks a highly motivated biologist with a strong background in signaling pathways and their perturbations in disease. This position will be an integral part of the biology group and will help drive the identification and validation of new targets for entry into the drug discovery portfolio. You will work across therapeutic functions with a primary focus in oncology and/or immunology. The scientist will extend our existing technical expertise to enhance and accelerate our platform development. We are keen to identify someone who is a self-starter and proactive and who can work effectively with a team of multidisciplinary scientists.

Responsibilities

  • Identify, evaluate, design and execute experiments for validation of novel targets in the Oncology, inflammation and immunology space
  • Collaborate with colleagues within other functions in the organization to devise plans for new target triage. Work closely with the platform group to systematically evaluate targets
  • Exploration of drug-target-phenotype relationships using chemical proteomics
  • Phenotypic in vitro assay development, data generation and analysis, and communication to scientific team and executive management.
  • Review of scientific, clinical, and patent literature to identify new target opportunities
  • Help lead strategy and planning of early-stage research programs, including identifying, evaluating, and championing new ideas and technologies
  • Help the biology team in identifying the relevant disease indications for the “targets” of interest
  • Utilize genomics-based tools for new target identification and validation
  • Develop disease relevant cellular models, using RNAi and CRISPR based tools for validating the target biology

 

Required Qualifications

    • Ph.D. with 5-8 years of experience in cell biology or related discipline with a strong publication record. 2 to 5+ years of experience in biotech/ pharmaceutical industry
    • Experience leading discovery biology efforts on project teams at various stages of the programs including target discovery/validation and lead optimization to IND-enabling studies
    • Previous work leading early discovery programs with novel target identification and validation responsibilities
    • Strong understanding of cancer cell signaling pathways and experience with target engagement, functional and phenotypic assays
    • Experience working with genomics, human genetics, and next-generation sequencing datasets, ideally in collaboration with computational teams
    • Experience in utilizing genomics-based technologies, including RNA-seq, ChIP-seq
    • Experience with gene modulation techniques in cell-based studies (RNAi, CRISPR, cDNA overexpression, etc.)
    • Experience with utilizing chemical biology tools and establishing biochemical assays is a plus
    • Ability to work effectively as an individual and as a member of multi-disciplinary project teams and present at team meetings
    • Good problem-solving skills with excellent interpersonal skills and a collaborative work style
    • Excellent written and verbal communication skills

 

All fully qualified applicants who are authorized to work in the US at the time of application will receive consideration for employment without regard to race, religion, gender, sexual orientation, national origin, ancestry, disability, veteran status, as protected under law.

To apply for the position, email a cover letter and resume to careers@exo-therapeutics.com

Interested in joining our team? Explore careers

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